منابع مشابه
T reg cells get specific
Naturally occurring regulatory T (T reg) cells suppress T cell–driven autoimmunity and chronic inflammation. Although the origin and function of these cells has been widely studied, the specificity of their T cell receptors (TCRs)—whether for self or foreign antigens on target cells—remains a matter of debate. Prevailing opinion comes down on the side of self-antigen. But now Suffia and colleag...
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Background: Chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. In vitro studies have been shown that Arteether (ARE) induces apoptosis in tumor cells, but not in normal cells. Objective: To investigate the cytotoxic and immunomodulatory properties of Arteether in-vivo and in-vitro. Methods: In this study, we ...
متن کاملIn vivo sites and cellular mechanisms of T reg cell–mediated suppression
Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell-T reg cell contact in vivo has not been ascertained. Varying answers to these imp...
متن کاملbrother's keeper
Families cannot be exchanged or denied. There is a sad futility about wishing our families were otherwise. So it is with the community of general practitioners to which we all belong. We share the same title, and will be judged collectively whether we like it or not. We may not want to account for some of our colleagues. We may try to surround ourselves with like-minded doctors and pretend that...
متن کاملRunx proteins regulate Foxp3 expression
Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets. In regulatory T (T reg) cells, the signature transcription factor Foxp3 interacts with and modulates the function of several other DNA binding...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2009
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20611iti4